cailynn- What is the main advantage of incorporating biotin into doxorubicin liposomes?Biotin is used to enhance the targeting capabilities of doxorubicin liposomes. Through the high-affinity binding interaction between biotin and avidin or streptavidin, these liposomes can be directed more efficiently to biotin-receptor expressing cells, improving the delivery of doxorubicin to target cancer cells.
- How does the PEGylation of biotin-doxorubicin liposomes contribute to their function?PEGylation extends the circulation time of the liposomes in the bloodstream by creating a hydrophilic barrier around the liposomes. This reduces opsonization by the mononuclear phagocyte system, thereby preventing premature clearance from the bloodstream and allowing more time for the liposomes to reach and accumulate at the tumor site.
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Biotin-Doxorubicin Liposome
